Below are the characters from anime who are hardest to kill:
1. Kars (Jojo’s Bizarre Adventure)

Kars is the first character from the anime Jojo’s Bizarre Adventure. He is described as one of the strongest characters in the anime universe due to his many unique abilities, such as manipulating light and accessing the DNA of living beings. Even in the end, when he was defeated, Kars still could not die.
2. Hidan (Naruto)

Next up is Hidan from the anime Naruto. Hidan is said to possess immense power because of his devotion to the Jashin religion. This makes him unable to die, even after Shikamaru has captured and cut him. He may have been defeated after Shikamaru’s strategy, but taking Hidan’s life remains incredibly difficult.
3. Kaido (One Piece)

Kaido is a member of the Beast Pirates and is known to be extremely difficult to kill despite having gone through many battles and attempts at execution. In reality, he has tried to end his own life hundreds of times but has always survived.
4. Ryuk (Death Note)

Next is Ryuk, the Shinigami from the anime Death Note. While Shinigami can die, killing Ryuk is incredibly challenging because he is immune to all human-made death methods. The only way to potentially kill a Shinigami is through being bound by Shinigami law, which can vary across different levels of gods.
5. Alucard (Hellsing)

Alucard is a powerful vampire in the anime Hellsing. Although he cannot die in the traditional sense, Alucard’s existence is sustained through the souls he absorbs from other beings, making him effectively immortal.
6. Ban (The Seven Deadly Sins)

Ban is the personification of greed within The Seven Deadly Sins. He is also known as Ban the Fox Sin of Greed due to his ability to steal and recover from any injury after drinking the “Fountain of Youth.”
7. C.C. (Code Geass)

C.C. is believed to have lived for centuries. Her Geass power allows her to grant immortality to others, though she herself is immune to aging and conventional methods of dying. She has survived countless attempts on her life, maintaining her existence despite various challenges.
8. Kyubey (Puella Magi Madoka Magica)

In the eighth position is Kyubey from the anime Puella Magi Madoka Magica. Kyubey is described as a character capable of sacrificing himself to maintain his own existence when faced with death. Not only that, but his abilities also extend beyond simple survival, possessing knowledge and power that make him a formidable opponent.
9. Zombie Man (One Punch Man)

True to his name, this character has abilities similar to a zombie and can regenerate quickly. He is an experiment that has successfully achieved immortality through the use of the advanced genetic material from the villain Genus, having escaped and lived for over ten years since then.
10. Saitama (One Punch Man)

Although not technically an immortal being, Saitama possesses overwhelming strength that makes him nearly impossible to kill. He can even withstand the impact of a falling meteor without harm. Saitama has the ability to end his own life if he so chooses, but his power keeps him in a position where he rarely faces death.